赵添堃，副教授，硕士研究生导师
甘肃省兰州市七里河区彭家坪路36号衡鉴楼-405
课题组网站：https://www.labxing.com/-20180038
Email: zhaotiankun@lut.edu.cn
Tel:13679480596 (微信同号)
【教育和工作经历】
2024-2025，访问学者，Instituto Superior Técnico，Universidade de Lisboa.
2019.2-今，副教授，兰州理工大学生命科学与工程学院
2016.2-2018.1，博士后，Texas A&M University （Prof. Marcetta Y Darensbourg）
2011.8-2015.11，博士，University of Konstanz (Prof Ulrich Groth and Prof Huhn Thomas)
2010.8-2011.7，中化（宁波）集团有限公司
2007.9-2010.6，硕士，上海大学化学系
2003.9-2007.6，本科，郑州大学药学院
【讲授课程】
药物合成反应，新药设计学，制药工程专业英语
【研究方向】
具有抗癌/抗菌活性的非铂类金属配合物设计合成与分子作用机制
【科研项目】
主持及参与国家级（No. 22267011），甘肃省科技厅科技专员专项（26CXGA061），省部级科研项目（2025A-035；25CXJA007；25CXJA008；24CXJA005，20JR5RA470）及企业研发项目十余项。创新引导计划—科技专员专项（26CXGA061）
【社会兼职】
白银京宇新药业有限公司科技创新特聘专家
【论文著作】
（1） Zhao, T.*; Zhao J.; Ma J.; Mei D.; Ding Y.; Qin Q.;Correia, I.;Liang H. GPX4-Targeting Phenolato ZrIV Complexes Induce Ferroptosis and Lysosome-Dependent Cell Death for Immunotherapy of Chemoresistant Cancer. J. Med. Chem. 2026, 69(13), 15974–15995.
（2） Kong X.; Zhang L.; Wang W.; Zhao, T.*; Lv B.; Ma J.; Ma Z.; Mao X.A water-stable trinuclear thulium(III) 8-hydroxyquinolinate complex: Synthesis, crystal structure, antitumor activity, and mechanistic studies. Inorg. Chem. Commun. 2026, 191, 117051.
（3） Zhao, T.*; Lv, B.; Ding Y.; Mei, D.; Ma J.; Zhang Q.; Zhang L.;Qin Q.;Yang Z.; Li S.; Correia, I.;Liang H.; Li A.Synthesis, characterization, and antimicrobial properties of 8-Hydroxyquinoline-based group 4 metal complexes for plant pathogen control. Pestic. Biochem. Physiol. 2026, 221, 107172.
（4）Zhao, T.*; Zhang Q.; Mei D.; Zhou Y.; Zhao J.; Lv B.; Ma J., Huhn, T.; Qin Q.; Liang H.;Correia, I. Phenolato TiIV Complexes as Bifunctional Antitumor Agents: Synergistic Photodynamic Therapy, In Situ TiIII-Mediated Cytotoxicity, and Immune Activation. J. Med. Chem. 2026, 69 (7), 8316-8339.
（5） Yuan, H.; Pei, M.; Lv, B.; Mei, D.; Zhou, Y.; Wang, L.; Pu, X.; Zhao, T.*2-Nitroethenyl Ferrocene as a Photosensitizer: Evaluation of Its Photodynamic Antitumor Properties. J. Organomet. Chem.2025, in press.
（6）Zhao, T.*; Mei, D.; Ma, J.; Liu, N.; Zhang, Q.; Yang, Z.; Correia, I. Anti-tumor and Cellular Mechanisms of HfIV Tetra-(8-hydroxyquinolinato) Complexes. J. Inorg. Biochem. 2025, 270, 0162-0134.
（7）Zhao, T.*; Zhang, Q.; Zhao, J.; Mei, D.; Ma, J.; Correia, I.; Yang, Z.; Kim, S.-H.; Huhn, T. Synthesis and X-ray Structure Analysis of Cytotoxic 2-picolylamino-type HfIV-bis-chelated Complexes. Dalton Trans.2025,54 (16), 6674–6683.
（8） Zhou, Y..; Zhao, T.*;Tao, S.; Wang, P.; Guan, Y..; Yang, K.; Chen, S..; Pu, X*.Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti-tumor Metallic Complexes. Chem. Asian J.2024, 19 (3), e202301020.
（9） Li, S.; Zhang, X.; Zhao, T.*; Liu, N.; Zhang, Y.; Wang, P.; Yang, Z.; Huhn, T.Synthesis, in Vitro Antitumor Evaluation and Structure–Activity Relationship of Heptacoordinated Amino-bis(Phenolato) Ti(IV) Complexes Stabilized by 2,6-Dipicolinic Acid. J. Biol. Inorg. Chem.2024, 29, 315–330.
（10） Zhao, W.; Yuan, P.; Zhang, Q.; Liu, N.; Wang, Y.; Wang, P.; Huhn, T.; Yang, Z.; Zhao, T.* Novel Bimetallic Oxido-bridged Phenolato Hafnium(IV) Complex with Enhanced Anti-tumor Activity and Aqueous Stability. Res. Chem.2023, 6, 2211–7156.
（11） Yang, M.; Liu, N.; Wang, P.; Zhao, T.* Synthesis and Cytotoxicity Study of Water Soluble 8-hydroxyquinoline Stabilized Zirconium(IV) Complexes. Inorg. Chem. Commun.2023, 153, 1387–7003.
（12）Zhao, T.*; Zhang, Y.; Wang, P.; Li, S.; Yang, Z.; Yang, M.Synthesis and Nitric Oxide Release Study of Dinitrosyl Cobalt Complexes.Inorg. Chem. Commun.2023,149, 1387–7003.
（13）Zhao, T.*; Wang, P.; Zhang, X.; Liu, N.; Zhao, W.; Zhang, Y.; Yuan, P.; Li, S.; Yang, M.; Yang, Z.; Huhn, T. Anti-tumoral Titanium(IV) Complexes Stabilized with Phenolato Ligands and Structure–Activity Relationship. Curr. Top. Med. Chem.2023, 23 (19), 1835–1849.
（14）Zhao, T.*; Wang, P.; Liu, N.; Zhao, W.; Yang, M.; Li, S.; Yang, Z.; Sun, B.; Huhn, T. Synthesis and X-ray Structure Analysis of Cytotoxic Heptacoordinated Salan Hafnium(IV) Complexes Stabilized with 2,6-Dipicolinic Acid. J. Inorg. Biochem.2023,240, 112094.
（15）Zhao, T.*; Wang, P., Liu, N., Li, S., Yang, M., & Yang, Z, Facile synthesis of [ONON] type titanium(IV) bis-chelated complexes in alcoholic solvents and evaluation of anti-tumor activity, J. Inorg. Biochem, 2022,235, 111925.
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