郭晓鹏，男，理学博士。研究方向包括：（1）微生物菌种选育及相关方法学和机理研究；（2）根际和内生菌增强植物品质的微生态机制和分子机理；（3）微生态改良和生物修复相关的优良微生物创制。

研究论文（通讯作者或第一作者）

1.  Xiaopeng Guo, Shengli Zhang, Runsheng Yin, Shuhua Zhu, Bin Ji, Yinan Peng, Shuhan Zhang, Xiuyue Xiao, Cheng Peng, Yonggang Wang^※. Soil nutrients, rhizosphere bacteria, and endophytes interact to influence the accumulation of amino acid-short peptide components in Angelica sinensis roots, each playing distinct roles. Rhizosphere 2025. DOI: 10.1016/j.rhisph.2025.101027

2. Xiaopeng Guo, Xuee Li, Shengli Zhang, Ying Sun^※, Bin Ji, Yinan Peng, Hushan Shang, Yue Wu. Integrated analysis of the microbiome, culturable strains, and substrate microenvironment reveals significant shifts in bacterial community of Angelica sinensis from fresh roots to medicinal slices. Biologia 2025. DOI: 10.1007/s11756-025-01885-9

3.  Haiwei Ren, Zhijuan Li, Qin Zhou, Hongyuan Zhao, Donglin Ma^※, Xiaopeng Guo^※, Zaoning Cai, Yantao Li, Zhiliang Zhang, Yi Zheng. Multi-omics analysis of microbial spatiotemporal succession and metabolite differences in pit mud of varying cellar ages and spatial positions. Food Chemistry: X 2025. DOI: 10.1016/j.fochx.2025.102287

4.  Xiaopeng Guo, Shengli Zhang, Cairong Lei, Chenglin Jia, Runsheng Yin, Miaomiao Zhang, Wei Liu^※, Dong Lu^※. Oligotrophic state reduces the time dependence of the observed survival fraction for heavy ion beam-irradiated Saccharomyces cerevisiae and provides new insights into DNA repair. Applied and Environmental Microbiology 2024. DOI: 10.1128/aem.01113-24

5.  Xiaopeng Guo, Xuee Li, Shengli Zhang, Shuhua Zhu, Rong Guo, Yue Gao, Yonggang Wang^※, Xiaofeng Liu, Yan Liu, Hao Shi. A joint analysis of metabolomics, network pharmacology, and molecular docking reveals the efficacy patterns in various medicinal segments of Angelica sinensis (Oliv.) Diels root. Journal of Food Biochemistry 2024. DOI: 10.1155/2024/7377627

6.  Chenglin Jia, Ran Chai, Miaomiao Zhang, Xiaopeng Guo^※, Xiang Zhou, Nan Ding, Dong Lu^※. Improvement of Saccharomyces cerevisiae strain tolerance to vanillin through heavy ion radiation combined with adaptive laboratory evolution. Journal of Biotechnology 2024, 394: 112-124. DOI:10.1016/j.jbiotec.2024.08.014

7.  Junle Ren, Miaomiao Zhang, Xiaopeng Guo^※, Xiang Zhou, Nan Ding, Cairong Lei, Chenglin Jia, Yajuan Wang, Jingru Zhao, Ziyi Dong, Dong Lu^※. Furfural tolerance of mutant Saccharomyces cerevisiae selected via ionizing radiation combined with adaptive laboratory evolution. Biotechnology for Biofuels and Bioproducts 2024, 17(1):117. DOI: 10.1186/s13068-024-02562-w

8.  Cairong Lei, Xiaopeng Guo^※, Miaomiao Zhang^※, Xiang Zhou, Nan Ding, Junle Ren, Meihan Liu, Chenglin Jia, Yajuan Wang, Jingru Zhao, Ziyi Dong, Dong Lu^※. Regulating the metabolic flux of pyruvate dehydrogenase bypass to enhance lipid production in Saccharomyces cerevisiae. Communications Biology 2024. DOI: 10.1038/s42003-024-07103-7.

9.  Ying Sun, Rong Guo, Yuting Geng, Hushan Shang, Xiaopeng Guo^※, Yue Wu, Yonggang Wang^※, Li Li, Xuee Li, Shengli Zhang, Ning Xu, Xueyan Li. Longitudinal distribution map of the active components and endophytic fungi in Angelica sinensis (Oliv.) Diels root and their potential correlations. Metabolites 2024, 14(1): DOI: 10.3390/metabo14010048

10.  Xiaopeng Guo, Junle Ren, Xiang Zhou, Miaomiao Zhang^※, Cairong Lei, Ran Chai, Lingxi Zhang, Dong Lu^※. Strategies to improve the efficiency and quality of mutant breeding using heavy-ion beam irradiation. Critical Reviews in Biotechnology 2024, 44(5): 735-752. DOI: 10.1080/07388551.2023.2226339

11.  Haiwei Ren, Yifan Sun, Yefei Yang, Yunfan Li, Xiaopeng Guo^※, Bingyun Zhang, Hongyuan Zhao, Donglin Ma^※, Zhiliang Zhang. Unraveling the correlations between microbial communities and metabolic profiles of strong-flavor Jinhui Daqu with different storage periods. Food Microbiology 2024, 121: 104497. DOI: 10.1016/j.fm.2024.104497

12.  Haiwei Ren, Zaoning Cai, Caixia Du, Zhijuan Li, Xiaopeng Guo^※, Yonggang Wang^※, Donglin Ma, Bingyun Zhang, Yi Zheng. Interrelated spatiotemporal variations between bacterial community and physicochemical factors in pit mud of Chinese strong-flavor Baijiu. LWT-Food Science and Technology 2024, 192: 115630. DOI: 10.1016/j.lwt.2023.115630

13.  Ying Sun, Meihan Liu, Dong Lu, Yumei Wang, Li Li, Yue Wu, Lingxi Zhang, Qinke Xv, Ruoqi Li, Tingyuan Liu, Tao Lu, Zhaohui Guo, Xiaopeng Guo^※. Large-scale microbiome analysis reveals bacterial community characteristics in typical Chinese herbal slices. Biologia 2022, 77(12): 3565-3580. DOI: 10.1007/s11756-022-01199-0

14.  Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Dong Lu^※, Wenjian Li, Libin Zhou. Repair characteristics and time-dependent effects in response to heavy-ion beam irradiation in Saccharomyces cerevisiae: a comparison with X-ray irradiation. Applied Microbiology and Biotechnology 2020, 104(9): 4043-4057. DOI: 10.1007/s00253-020-10464-8

15.  Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Guozhen Cao, Dong Lu^※, Wenjian Li. Quantitative multi-omics analysis of the effects of mitochondrial dysfunction on lipid metabolism in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 2020, 104(3): 1211-1226. DOI: 10.1007/s00253-019-10260-z

16.  Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Guozhen Cao, Yang Yang, Dong Lu^※, Wenjian Li^※. A genome-wide view of mutations in respiration-deficient mutants of Saccharomyces cerevisiae selected following carbon ion beam irradiation. Applied Microbiology and Biotechnology 2019, 103(4): 1851-1864. DOI: 10.1007/s00253-019-09626-0

17.  Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Wenjian Li, Dong Lu^※. “Saddle-shaped” dose-survival effect, is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation? Annals of Microbiology 2019, 69(3): 221-232. DOI: 10.1007/s13213-019-1442-7

18. Xiaopeng Guo, Miaomiao Zhang, Ruiyuan Liu, Yue Gao, Yang Yang, Wenjian Li, Dong Lu^※. Repair characteristics and time-dependent effects in Saccharomyces cerevisiae cells after X-ray irradiation. World Journal of Microbiology and Biotechnology 2018, 35(1): 1. DOI: 10.1007/s11274-018-2566-9

19. Xiaopeng Guo, Miaomiao Zhang, Yue Gao, Wenjian Li, Dong Lu※. Determining survival fractions of Saccharomyces cerevisiae in response to ionizing radiation in liquid culture. Journal of Radiation Research 2018, 59(6): 760-764. DOI: 10.1093/jrr/rry070